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Since nephrotoxic and/or neurotoxic effects may be additive, concurrent or sequential use of colistimethate sodium and other drugs with similar toxic potentials (e.g., aminoglycosides, amphotericin B, capreomycin, methoxyflurane, polymycin B sulfate, vancomycin) should be avoided, if possible.
Neuromuscular blocking agents (e.g., tubocurarine, succinylcholine, ether, decamethonium, gallamine and other drugs (e.g., sodium citrate) potentiate neuromuscular blockade induced by colistimethate sodium and these drugs should be used with extreme caution on patients receiving colisfunethate sodium.
